NAPLEX Online Practice Questions and Answers

Which of the following represents the major route of metabolism for acetaminophen?

A. Glucuronidation

B. Sulfation

C. Cytochrome P-450 oxidation

D. Direct renal excretion

E. Plasma breakdown

Your patient, a 25-year-old G1P0 female at 26 weeks gestation presents due to an abnormal glucose tolerance test. One week prior, she was given 50 g of oral glucose and demonstrate a venous plasma glucose level of 156 mg/dL one hour later.

Which of the following is the most appropriate next step of management?

A. Repeat the 50 g oral glucose challenge

B. Administer an oral, 3-hour 100 g glucose dose

C. Advise the patient to follow an American Diabetic Association diet plan

D. Begin insulin treatment

E. Order a fetal ultrasound examination

LN is 84 YOM who is in hospital for a back surgery. His height is 5 feet and 4 inches, weight 85 kg and NKDA. His past medical history includes hypertension, diabetes mellitus, major depression, hypothyroidism and chronic back pain.

Post-op day 1, LN's medication includes Dexamethasone 8 mg iv q6h with taper dosing, Ondansetron 4 mg iv q6h prn for N/V, Levothyroxine 0.075 mg po daily, Lisinopril 10 mg po daily, Citalopram 20 mg po daily, Docusate sodium / Senna 1 tab po twice a day, Bisacodyl 10 mg suppository daily prn for constipation, Famotidine 20 mg iv q12hr, Metoclopramide 10 mg iv q6h, Metformin 500 mg po bid, D51/2NS with 20 K at 125 mls/hour and Hydromorphone PCA at 0.2 mg/hour of basal rate, demand dose

0.1

mg. lock-out every 6 min, one hour limit 2.2 mg/hour. Pertinent morning labs includes serum creatinine

1.4

mg/dl, Mg 1.5 mg/dl, K 5.0 mmol/L, Na 135 mmol/L.

Which of the following medication may increase LN's Blood glucose?

A. Lisinopril

B. Dexamethasone

C. Famotidine

D. Metoclopramide

E. Hydromorphone

You need 51.3 mEq of NaCl to make 1/3 NS 1 liter bag. How many ml of 23.4% NaCl would you need? (Molecular weight of Na is 23 and Cl is 35.5)

A. 12.82ml

B. 16.82ml

C. 23.4ml

D. 58.5ml

E. 10ml

An order is received for heparin 18 units per kg per hour on a patient whose weight is 125lb. The IV bag comes as a concentration of 50 units /mL. Calculate the infusion rate in terms of mL/hr.

A. 5.15 mls/hr

B. 10.23 mls/hr

C. 40.9 mls/hr

D. 20.45 mls/hr

E. 18 mls/hr

Which of the following is/are ordinal data?

A. NYHA I-IV

B. Grade of breast cancer

C. Sex

D. Improvement Yes/No

E. Alive or Dead

In Normal distribution, what percentage of the sample is found within 2 standard deviation of the mean?

A. 68%

B. 95%

C. 99%

D. 100%

E. 72%

Which of the following class of antidiabetic medications can increase triglycerides?

A. Bile acid sequestrant

B. GLP-1 agonist

C. Thiazolidinediones

D. SGLT2 Inhibitor

E. Alpha-glucosidase inhibitors

FT is a 23-year-old newly diagnosed type I diabetes admitted to the hospital due to diabetes ketoacidosis. 2 days after being on insulin drip, anion gap is closed. Physician would like your help in transitioning her to subcutaneous insulin. She suggests using insulin glargine once a day and Insulin lispro three time a day at ratio of 70:30. 70 % of long and 30 % of short acting insulin. FT received average of 70 units of insulin in 24hrs.

Which of the following would be the best insulin regimen?

A. 49 units of Insulin Glargine subcutaneous daily and 7 units of Insulin Lispro subcutaneous three times a day with meals

B. 25 units of Insulin Glargine subcutaneous daily and 15 units of Insulin Lispro subcutaneous three times a day with meals

C. 40 units of Insulin Glargine subcutaneous daily and 10 units of Insulin Lispro subcutaneous three times a day with meals

D. 46 units of Insulin Glargine subcutaneous daily and 8 units of Insulin Lispro subcutaneous three times a day with meals

E. 52 units of Insulin Glargine subcutaneous daily and 6 units of Insulin Lispro subcutaneous three times a day with meals

JK is a 67 years old African American man who presents to your clinic for his blood pressure management. His past medical history includes Peptic ulcer disease and hypertension. His two BP readings are 160/98, 159/96 and HR 85. He says he has been adherent to his medication and lifestyle. He currently takes 12.5mg Chlorthalidone and Prilosec 20mg daily.

Which of the following is the best strategy to manage his blood pressure?

A. Increase chlorthalidone to 25mg daily

B. Add Norvasc 2.5 daily

C. Add Lisinopril 5mg daily

D. Add hydrochlorothiazide 25mg daily

E. Add Lisinopril 20mg daily

Number of new cases per population at risk in a given time period is a definition of which of the following?

A. Incidence rate

B. Prevalence rate

C. Mortality rate

D. Odds ratio

E. Confidence Interval

Which of the following would be most appropriate to treat infections associated with stenotrophomonas maltophilia?

A. Meropenem

B. Vancomycin

C. Ciprofloxacin

D. Sulfamethoxazole/trimethoprim

E. Ampicillin

Which of the following are non-pharmacological measure that may control symptoms of gastroesophageal reflux disease?

A. Remain upright after a meal

B. Increase fat intake to reduce gastric emptying time Reduce intake of food or beverage that may reduce

C. lower esophageal sphincter tone

D. Wear tight fitted cloths to increase intra-abdominal pressure.

E. Discontinue nicotine use in patients that uses tobacco product.

MT is 47-year-old man who presents to the ER with painful, red, swollen area on his left leg. His temperature is 38.4, respiratory rate 30 and heart rate 95. He has been taking cephalexin day 4 today, as prescribed by his primary care physician. His CMP is normal a CBC shows elevated WBC of 16,000/mm3.

What would be the most appropriate antibiotic/s to initiate on MT empirically?

A. Vancomycin IV and Piperacillin/Tazobactam

B. IV Doxycycline and Ceftazidime

C. Nafcillin

D. Vancomycin IV.

E. Ceftriaxone

The administration of dapsone gel for the topical treatment of acne vulgaris in patients with G6PD deficiency may produce which of these?

A. Anaphylaxis

B. Fungal infections

C. Hemolysis

D. Immunosuppression